論文 (2011~ 迄今)

1. 1. Tzu-Ching Yang, Yun-Jou Chiang, Po-Yu Chiang, Han-Yu Chen, Kai-Ru Zhuang, Yu-Chia Wang, Chao-Hsiung Lin, Lee-Chiang Lo* and Shu-Ling Fu* (2023) “Design, synthesis, and anti-cancer evaluation of C-14 arylcarbamate derivatives of andrographolide”, Bioorganic and Medicinal Chemistry, 98: 117582.
   2. Shih-Ming Ou, Yin-Chieh Hsu, Shu-Ling Fu, Lie-Chwen Lin, and Chao-Hsiung Lin (2023) “Galgravin isolated from Piper kadsura ameliorates lipopolysaccharide (LPS)-induced endotoxemia in mice”, International Journal of Molecular Sciences, 24: 16572.
   3. Chien-Tung Wu, Yueh-Ting Tsai, Yi-Ting Hsieh, Shu-ling Fu, Jung-Nien Lai (2023), “Traditional herbal medicine and the decreased risk of uterine surgery among women with uterine fibroid in Taiwan”, Journal of Herbal Medicine, 42: 100759.
   4. Yong-Hong Yang, Che-Sheng Wen, Yung-Ling Kuo, Su-Ling Fu, Tung-Yi Lin, Chao-Ming Chen, Po-Kuei Wu, Wei-Ming Chen, Jir-You Wang (2023), “GuiLu-ErXian Glue extract promotes mesenchymal stem cells (MSC)-Induced chondrogenesis via exosomes release and delays aging in the MSC senescence process”, Journal of Ethnopharmacology 317: 116784.
   5. Yin-Chieh Hsu, Shih-Ming Ou, Kai-Ru Zhuang, Ai-Ling Kuo, Wan-Jhen Li, Chun-Yi Huang, Chao-Hsiung Lin, Jih-Jung Chen and Shu-Ling Fu* (2023), “Hypericum sampsonii exhibits anti-inflammatory activity in a lipopolysaccharide-induced sepsis mousemodel”, Journal of Traditional and Complementary Medicine, 13: 379-388.
   6. Yi-Ju Chou, Ching-Cheng Lin, Ya-chi Hsu, Jia-Ling Syu, Ling-Ming Tseng, Jen-Hwey Chiu, Jeng-Fan Lo, Chao-Hsiung Lin, and Shu-Ling Fu* (2022),“Andrographolide suppresses the malignancy of triple-negative breast cancer by reducing THOC1-promoted cancer stem cell characteristics”, Biochemical Pharmacology, 206: 115327.
   7. Kai-Wei Chang, Tung-Yi Lin, Shu-Ling Fu, Yueh-Hsin Ping, Fang-Pey Chen, Yen-Ying Kung (2022), “A Houttuynia cordata-based Chinese herbal formula improved symptoms of allergic rhinitis during the COVID-19 pandemic”, Journal of the Chinese Medical Association, 85:717-722.
   8. Yueh-Hsin Ping, Hsin Yeh, Li-Wei Chu, Zhi-Hu Lin, Yin-Chieh Hsu, Lie-Chwen Lin, Chung-Hua Hsu, Shu-Ling Fu*, Tung-Yi Lin* (2022), “The Traditional Chinese Medicine Formula Jing Guan Fang for preventing SARS-CoV-2 infection: from clinical observation to basic research”, Frontiers in Pharmacology, 13:744439.
   9. Yi-Cheng Chu, Chang-Syun Yang, Ming-Jen Cheng, Shu-Ling Fu*, and Jih-Jung Chen* (2022), “Comparison of various solvent extracts and major bioactive components from unsalt-fried and salt-fried rhizomes of Anemarrhena asphodeloides for antioxidant, anti-α-Glucosidase, and anti-acetylcholinesterase activities”, Antioxidants, 11: 385.
   10. Yi-Hue Kuo, Shih-Hsiang Wei, Jie-Hau Jiang, Yueh-Shih Chang, Mei-Yin Liu, Shu-Ling Fu, Chi-Ying F Huang, Wey-Jinq Lin* (2021), “Perturbation of p38α MAPK as a Novel Strategy to Effectively Sensitize Chronic Myeloid Leukemia Cells to Therapeutic BCR-ABL Inhibitors”, International Journal of Molecular Sciences, 22:12573.
   11. Lin-Chieh Chiu, Jir-You Wang, Chao-Hsiung Lin, Chung-Hua Hsu, Lie-Chwen Lin* and Shu-Ling Fu* (2021), “Diterpenoid compounds isolated from Chloranthus oldhamii Solms exert anti-inflammatory effects via inhibiting IKK/NF-κB pathways”, Molecules, 26: 6540.
   12. Chien-Tung Wu, Yueh-Ting Tsai, Hsuan-Kuang Jung, Shu-ling Fu, Chao A. Hsiung, Hsiao-Yu Liu, Jung-Nien Lai (2021), “Metformin and the risk of anemia of advanced chronic kidney disease in patients with Type 2 Diabetes mellitus”, The Journal of Clinical Pharmacology, 62:276-284.
   13. Chiao-Che Chen, Jen-Hao Yang, Shu-Ling Fu, Wey-Jinq Lin and Chao-Hsiung Lin* (2021), “Arginine methylation of hnRNPK inhibits the DDX3-hnRNPK interaction to Play an Anti-Apoptosis Role in Osteosarcoma Cells”, International Journal of Molecular Sciences, 22: 9764.
   14. Yi-Cheng Chu, Chun-Hao Chang, Hsiang-Ruei Liao, Shu-Ling Fu and Jih-Jung Chen* (2021), “Anti-cancer and anti-Inflammatory activities of three new chromone derivatives from the marine-derived Penicillium citrinum”, Marine Drugs, 19: 408.
   15. Yi-Cheng Chu, Chun-Hao Chang, Hsiang-Ruei Liao, Ming-Jen Cheng, Ming-Der Wu, Shu-Ling Fu* and Jih-Jung Chen* (2021), “Rare chromone derivatives from the marine-Derived Penicillium citrinum with anti-cancer and anti-Inflammatory activities”, Marine Drugs, 19: 25.
   16. Cai-Wei Li, Yi-Cheng Chu, Chun-Yi Huang, Shu-Ling Fu and Jih-Jung Chen (2020) “Evaluation of Antioxidant and Anti-α-glucosidase Activities of Various Solvent Extracts and Major Bioactive Components from the Seeds of Myristica fragrans”, Molecules, 25:5198.
   17. Tzu-Hau Shi, Yi-Long Huang, Chiao-Che Chen, Wen-Chieh Pi, Yu-Ling Hsu, Lee-Chiang Loe Wei-Yi Chen, Shu-Ling Fu*, Chao-Hsiung Lin* (2020) “Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage”, Biochemical and Biophysical Research Communications, 533(3):467-473 (corresponding author).
   18. Yi-Ju Chou, Ching-Cheng Lin, Ivan Dzhagalov, Nien-Jung Chen, Chao-Hsiung Lin, Chun-Cheng Lin, Szu-Ting Chen, Kuo-Hsin Chen* and Shu-Ling Fu* (2020) “Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy”, Scientific Reports, 10: 8422 (corresponding author).
   19. Hsin-Yu Tsai, Shu-Ling Fu, Ling-Ming Tseng, Jen-Hwey Chiu & Chao-Hsiung Lin (2019) “hnRNPK S379 phosphorylation participates in migration regulation of triple negative MDA-MB-231 cells” Scientific Reports, 9: 7611.
   20. Hsin-Chia Liao, Yi-Ju Chou, Ching-Cheng Lin, Sheng-Hung Liu, Audrey Oswita, Yi-Long Huang, Ying-Lien Wang, Jia-Ling Syu, Chung-Ming Sun, Chuen-Miin Leu, Chao-Hsiung Lin and Shu-Ling Fu* (2019) “Andrographolide and its potent derivative exhibit anticancer effects against imatinib-resistant chronic myeloid leukemia cells by downregulating the Bcr-Abl oncoprotein”. Biochemical Pharmacology, 163: 308-320 (corresponding author).
   21. Yun-Chen Tsai, Sin-Ling Wang, Mei-Yao Wu, Chia-Huei Liao, Chao-Hsiung Lin, Jih-Jung Chen* and Shu-Ling Fu* (2018)“Pilloin, a flavonoid isolated from Aquilaria sinensis, exhibits anti-inflammatory activity in vitro and in vivo” Molecules, 23: e3177 (corresponding author).
   22. Chih-Chia Yu, Chien-An Chen, Shu-Ling Fu, Hon-Yi Lin, Moon-Sing Lee, Wen-Yen Chiou, Yu-Chieh Su, Shih-Kai Hung (2018) “Andrographolide enhances the anti-metastatic effect of radiation in Ras-transformed cells via suppression of ERK-mediated MMP-2 activity” PLOS one, 13: e0205666.
   23. Lin-Yang Cheng, Yun-Chen Tsai, Shu-Ling Fu, Ming-Jen Cheng, Ping-Jyun Sung, Mei-Ing Chung and Jih-Jung Chen (2018) “Acylphloroglucinol Derivatives from Garcinia multiflora with Anti-Inflammatory Effect in LPS-Induced RAW264.7 Macrophages ” Molecules, 23: e2587.
   24. Sin-Ling Wang , Yun-Chen Tsai , Shu-Ling Fu, Ming-Jen Cheng, Mei-Ing Chung and Jih-Jung Chen (2018) “2-(2-Phenylethyl)-4H-chromen-4-one Derivatives from the Resinous Wood of Aquilaria sinensis with Anti-Inflammatory Effects in LPS-Induced Macrophages” Molecules, 23: e289.
   25. Chien-Tung Wu, MD, Yueh-Ting Tsai, Jaung-Geng Lin, Shu-ling Fu, Jung-Nien Lai* (2018) “Chinese herbal products and the reduction of risk of breast cancer among females with type 2 diabetes in Taiwan “ Medicine, 97:e11600.
   26. Yun-Chen Tsai, Shih-Han Chen, Lie-Chwen Lin*, and Shu-Ling Fu*(2017) “Anti-inflammatory principles from Sarcandra glabra” Journal of Agricultural and Food Chemistry, 65: 6497-6505 (corresponding author).
   27. Shu-ling Fu, Chien-an Chen, Ling-chien Hung, Moon-Sing Lee, Wen-yen Chiou, Hon-Yi-Lin, Yu-Chien Su, Ching-Chih Lee and Shih-Kai Hung (2016) “Preliminary results of a non-invasive method to measure tumor size and distribution in vivo” Experimental and Therapeutic Medicine, 12: 3614-3620.
   28. Ya-Hsin Hsu, Yu-Ling Hsu, Sheng-Hung Liu, Hsin-Chia Liao, Po-Xuan Lee, Chao-Hsiung Lin, Lee-Chiang Lo, and Shu-Ling Fu* (2016) “Development of a bifunctional andrographolide-based chemical probe for pharmacological study” PLOS one, 11: e0152770 (corresponding author).
   29. Shu-Ling Fu, Chun-Cheng Lin, Ming-Ling Hsu, Yu-Jen Chen* (2016) ” CCL-34, a synthetic Toll-like receptor 4 activator, modulates differentiation and maturation of myeloid dendritic cells” Oncotarget, 7:11677
   30. Yu-Ling Hsu, Chun-Chieh Yang, Tzyy-Chao Chou, Chih-Hsuan Tai, Long-Yuan Chen, Shu-Ling Fu, Jing-Jer Lin, Lee-Chiang Lo* (2016) “Design, synthesis, and evaluation of cell permeable probes for protein kinases” Tetrahedron, 72: 58-68.
   31. Ya-Wei Liu, Yung-Tsung Chiu, Shu-Ling Fu, Yi-Tsau Huang* (2015) ” Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation” Journal of Biomedical Science, 22:63.
   32. Tsai-Feng Li, Ching-Cheng Lin, Hui-ping Tsai, Chung-Hua Hsu*, Shu-Ling Fu* (2014) “Effects of Kuan-Sin-Yin decoction on immunomodulation and tumorigenesis in mouse tumor models” BMC Complementary and Alternative Medicine, 14:488 (corresponding author).
   33. Yu-Chieh Su, Chih-Chia Yu, Fei-Ting Hsu, Shu-Ling Fu, Jeng-Jong Hwang, Ling-Chien Hung, Moon-Sing Lee, Wen-Yen Chiou, Hon-Yi Lin, Shih-Kai Hung (2014) “Everolimus sensitizes Ras-transformed cells to radiation in vitro through the autophagy pathway” International Journal of Molecular Medicine, 34: 1417-1422.
   34. Sheng-Hung Liu, Chao-Hsiung Lin, Fong-Ping Liang, Pei-Fen Chen, Cheng-Deng Kuo, Mujahid Alam, Barnali Maiti, Shih-Kai Hung, Chin-Wen Chi, Chung-Ming* Sun and Shu-Ling Fu* (2014) “Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy” Biochemical Pharmacology, 87:229-242 (corresponding author)..
   35. Jen-Hao Yang, Yi-Ying Chiou, Shu-ling Fu, I-Yun Shih, Tsai-Hsuan Weng, Wey-Jinq Lin and Chao-Hsiung Lin (2014) “Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation” Nucleic Acids Research, 42:9908-24.
   36. Yu-Ling Chang, Tzu-Hui Chen, Yi-Hsiu Wu, Guann-An Chen, Tzu-Huei Weng, Ping-Hui Tseng, Shie-Liang Hsieh, Shu-Ling Fu, Chi-Hung Lin, Chun-Jen Chen, Ching-Liang Chu, Iok In Christine Chio, Tak Wah Mak*and Nien-Jung Chen* (2014) “A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction” Journal of Cellular and Molecular Medicine 18:1344-57.
   37. Yong-Shiang Lin, Chao-Hsiung Lin, Li-De Huang, Tung Chao, Cheng-Deng Kuo, Ling-Chien Hung, Fen-Hwa Wong, Chun-Cheng Lin* and Shu-Ling Fu* (2013) “Suppression of thoc1 in cancer cell apoptosis mediated by activated macrophages is nitric oxide-dependent” Biochemical Pharmacology, 86: 242-252 (corresponding author).
   38. Kai-Wei Hsueh, Shu-Ling Fu, Chirn-Bin Chang, Yu-Ling Chang and Chao-Hsiung Lin (2013) “A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2” BBA – Proteins and Proteomics, 1834:508-515.
   39. Yi-Ying Chiou, Shu-Ling Fu, Wey-Jinq Lin, and Chao-Hsiung Lin (2012) “Proteomics analysis of in vitro protein methylation during Src-induced transformation” Electrophoresis, 33: 451-461.
   40. Yong-Shiang Lin, Li-De Huang, Chao-Hsiung Lin, Po-Hsiung Huang, Yu-Jen Chen, Fen-Hwa Wong, Chun-Cheng Lin*, and Shu-Ling Fu* (2011) “In vitro and in vivo anticancer activity of a synthetic glycolipid as TLR4 activator” Journal of Biological Chemistry, 286: 43782-43792 (corresponding author).
   41. Mei-Yao Wu, Shih-Kai Hung and Shu-Ling Fu* (2011) “Immunosuppressive effects of fisetin in ovalbumin-induced asthma through inhibition of NF-κB activity” Journal of Agricultural and Food Chemistry, 59: 10496-10504 (corresponding author).
   42. Kai-Wei Hsueh, Shu-Ling Fu, Chi-Ying F. Huang and Chao-Hsiung Lin (2011) ^“Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53” FEBS letters, 585: 2671-2675.
   43. Chia-Yuan Liu, Hsun-Shuo Chang, Ih-Sheng Chen, Chih-Jen Chen, Ming-Ling Hsu, Shu-Ling Fu^*, Yu-Jen Chen^* (2011) “Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells” Radiation Oncology, 6: 56 (corresponding author). `
   44. Li-De Huang, Hong-Jyune Lin, Po-Hsiung Huang, Wei-Chen Hsiao, L. Vijaya Raghava Reddy, Shu-Ling Fu* and Chun-Cheng Lin* (2011) “Synthesis of serine-based glycolipids as potential TLR4 activators” Organic & Biomolecular Chemistry, 9: 2492-2504 (corresponding author).