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系所成員

Department members

教師資料

現任

傳統醫藥研究所專任/中醫學系合聘

學經歷

學經歷
美國紐約州立大學石溪分校生化及細胞生物學博士
美國Scripps研究中心分子實驗醫學部博士後研究員

學術獎項
陽明大學教師學術卓越獎勵 (2017~2022)
院級教學傑出獎 (2021)

研究專長
癌症生物學、分子生物學、抗癌天然物及中草藥、抗發炎天然物及中草藥

研究方向
抗癌天然物藥理活性分析及作用機轉探討
降低癌化療副作用之天然藥物與醫藥組合物
抗發炎天然物的篩選及藥理活性分析
抑制新冠病毒的天然藥物開發

開設課程
抗癌天然物作用機轉、中醫藥實驗概論、傳統醫藥學概論

期刊審查委員:
Biochemical Pharmacology
Journal of Agricultural and Food Chemistry
Frontiers in Pharmacology
Phytomedicine
Phytochemistry
International Immunopharmacology
Pharmacological Research
Cell Death and Disease
British Journal of Pharmacology
Evidence-Based Complementary and Alternative Medicine
Experimental and Molecular Medicine
Molecules
Journal of Biomedical Science
Evidence-Based Complementary and Alternative Medicine
BMC cancer
Journal of Functional Food

專長

中藥藥理、癌症生物學、抗發炎、天然藥物開發

學術著作

論文 (2019~ 迄今)

  1. Kai-Wei Chang, Yen-Ying Kung*, Shu-Ling Fu, Ju-Fang Liu, Kun-Chang Wu, Tzu-Hau Shi, Yu-Han Luo, Chao-Hsiung Lin, Jih-Jung Chen, Yueh-Hsin Ping, Tung-Hu Tsai, Muh-Hwa Yang (2024) “Herbal-based tea bag reduces SARS-CoV-2 variant symptoms and infection duration via microRNA regulation: Clinical and mechanistic insights” Journal of Functional Foods, 122: 106530.
  2. Kai-Ru Zhuang, Chian-Feng Chen, Hsin-Yu Chan, Shin-E Wang, Dai-Heng Lee, Shih-Chin Chen, Bor-Uei Shyr, Yi-Ju Chou, Chiao-Che Chen, Shao-Ho Yuan, Yuan-I Chang, Hsueh-Te Lee, and Shu-Ling Fu* (2024) “Andrographolide suppresses the malignancy of pancreatic cancer via alleviating DNMT3B-dependent repression of tumor suppressor gene ZNF382”, Phytomedicine, 132: 155860. 通訊作者
  3. Tzu-Ching Yang, Yun-Jou Chiang, Po-Yu Chiang, Han-Yu Chen, Kai-Ru Zhuang, Yu-Chia Wang, Chao-Hsiung Lin, Lee-Chiang Lo* and Shu-Ling Fu* (2024) “Design, synthesis, and anti-cancer evaluation of C-14 arylcarbamate derivatives of andrographolide”, Bioorganic and Medicinal Chemistry, 98: 117582. 通訊作者
  4. Shih-Ming Ou, Yin-Chieh Hsu, Shu-Ling Fu, Lie-Chwen Lin, and Chao-Hsiung Lin (2023) “Galgravin isolated from Piper kadsura ameliorates lipopolysaccharide (LPS)-induced endotoxemia in mice”, International Journal of Molecular Sciences, 24: 16572.
  5. Yong-Hong Yang, Che-Sheng Wen, Yung-Ling Kuo, Su-Ling Fu, Tung-Yi Lin, Chao-Ming Chen, Po-Kuei Wu, Wei-Ming Chen, Jir-You Wang (2023), “GuiLu-ErXian Glue extract promotes mesenchymal stem cells (MSC)-Induced chondrogenesis via exosomes release and delays aging in the MSC senescence process”, Journal of Ethnopharmacology 317: 116784.
  6. Yin-Chieh Hsu, Shih-Ming Ou, Kai-Ru Zhuang, Ai-Ling Kuo, Wan-Jhen Li, Chun-Yi Huang, Chao-Hsiung Lin, Jih-Jung Chen* and Shu-Ling Fu* (2023), “Hypericum sampsonii exhibits anti-inflammatory activity in a lipopolysaccharide-induced sepsis mousemodel”, Journal of Traditional and Complementary Medicine, 13: 379-388. 通訊作者
  7. Yi-Ju Chou, Ching-Cheng Lin, Ya-chi Hsu, Jia-Ling Syu, Ling-Ming Tseng, Jen-Hwey Chiu, Jeng-Fan Lo, Chao-Hsiung Lin, and Shu-Ling Fu* (2022),“Andrographolide suppresses the malignancy of triple-negative breast cancer by reducing THOC1-promoted cancer stem cell characteristics”, Biochemical Pharmacology, 206: 115327. 通訊作者
  8. Kai-Wei Chang, Tung-Yi Lin, Shu-Ling Fu, Yueh-Hsin Ping, Fang-Pey Chen, Yen-Ying Kung (2022), “A Houttuynia cordata-based Chinese herbal formula improved symptoms of allergic rhinitis during the COVID-19 pandemic”, Journal of the Chinese Medical Association, 85:717-722.
  9. Yueh-Hsin Ping, Hsin Yeh, Li-Wei Chu, Zhi-Hu Lin, Yin-Chieh Hsu, Lie-Chwen Lin, Chung-Hua Hsu, Shu-Ling Fu*, Tung-Yi Lin* (2022), “The Traditional Chinese Medicine Formula Jing Guan Fang for preventing SARS-CoV-2 infection: from clinical observation to basic research”, Frontiers in Pharmacology, 13:744439. 通訊作者
  10. Yi-Cheng Chu, Chang-Syun Yang, Ming-Jen Cheng, Shu-Ling Fu*, and Jih-Jung Chen* (2022), “Comparison of various solvent extracts and major bioactive components from unsalt-fried and salt-fried rhizomes of Anemarrhena asphodeloides for antioxidant, anti-α-Glucosidase, and anti-acetylcholinesterase activities”, Antioxidants, 11: 385. 通訊作者
  11. Yi-Hue Kuo, Shih-Hsiang Wei, Jie-Hau Jiang, Yueh-Shih Chang, Mei-Yin Liu, Shu-Ling Fu, Chi-Ying F Huang, Wey-Jinq Lin* (2021), “Perturbation of p38α MAPK as a Novel Strategy to Effectively Sensitize Chronic Myeloid Leukemia Cells to Therapeutic BCR-ABL Inhibitors”, International Journal of Molecular Sciences, 22:12573.
  12. Lin-Chieh Chiu, Jir-You Wang, Chao-Hsiung Lin, Chung-Hua Hsu, Lie-Chwen Lin* and Shu-Ling Fu* (2021), “Diterpenoid compounds isolated from Chloranthus oldhamii Solms exert anti-inflammatory effects via inhibiting IKK/NF-κB pathways”, Molecules, 26: 6540. 通訊作者
  13. Chien-Tung Wu, Yueh-Ting Tsai, Hsuan-Kuang Jung, Shu-ling Fu, Chao A. Hsiung, Hsiao-Yu Liu, Jung-Nien Lai (2021), “Metformin and the risk of anemia of advanced chronic kidney disease in patients with Type 2 Diabetes mellitus”, The Journal of Clinical Pharmacology, 62:276-284.
  14. Chiao-Che Chen, Jen-Hao Yang, Shu-Ling Fu, Wey-Jinq Lin and Chao-Hsiung Lin* (2021), “Arginine methylation of hnRNPK inhibits the DDX3-hnRNPK interaction to Play an Anti-Apoptosis Role in Osteosarcoma Cells”, International Journal of Molecular Sciences, 22: 9764.
  15. Yi-Cheng Chu, Chun-Hao Chang, Hsiang-Ruei Liao, Shu-Ling Fu and Jih-Jung Chen* (2021), “Anti-cancer and anti-Inflammatory activities of three new chromone derivatives from the marine-derived Penicillium citrinum”, Marine Drugs, 19: 408.
  16. Yi-Cheng Chu, Chun-Hao Chang, Hsiang-Ruei Liao, Ming-Jen Cheng, Ming-Der Wu, Shu-Ling Fu* and Jih-Jung Chen* (2021), “Rare chromone derivatives from the marine-Derived Penicillium citrinum with anti-cancer and anti-Inflammatory activities”, Marine Drugs, 19: 25. 通訊作者
  17. Cai-Wei Li, Yi-Cheng Chu, Chun-Yi Huang, Shu-Ling Fu and Jih-Jung Chen (2020) “Evaluation of Antioxidant and Anti-α-glucosidase Activities of Various Solvent Extracts and Major Bioactive Components from the Seeds of Myristica fragrans”, Molecules, 25:5198.
  18. Tzu-Hau Shi, Yi-Long Huang, Chiao-Che Chen, Wen-Chieh Pi, Yu-Ling Hsu, Lee-Chiang Loe Wei-Yi Chen, Shu-Ling Fu*, Chao-Hsiung Lin* (2020) “Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage”, Biochemical and Biophysical Research Communications, 533(3):467-473通訊作者
  19. Yi-Ju Chou, Ching-Cheng Lin, Ivan Dzhagalov, Nien-Jung Chen, Chao-Hsiung Lin, Chun-Cheng Lin, Szu-Ting Chen, Kuo-Hsin Chen* and Shu-Ling Fu* (2020) “Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy”, Scientific Reports, 10: 8422 通訊作者
  20. Hsin-Yu Tsai, Shu-Ling Fu, Ling-Ming Tseng, Jen-Hwey Chiu & Chao-Hsiung Lin (2019) “hnRNPK S379 phosphorylation participates in migration regulation of triple negative MDA-MB-231 cells” Scientific Reports, 9: 7611.
  21. Hsin-Chia Liao, Yi-Ju Chou, Ching-Cheng Lin, Sheng-Hung Liu, Audrey Oswita, Yi-Long Huang, Ying-Lien Wang, Jia-Ling Syu, Chung-Ming Sun, Chuen-Miin Leu, Chao-Hsiung Lin and Shu-Ling Fu* (2019) “Andrographolide and its potent derivative exhibit anticancer effects against imatinib-resistant chronic myeloid leukemia cells by downregulating the Bcr-Abl oncoprotein”. Biochemical Pharmacology, 163: 308-320. 通訊作者

研究計畫

科技部計畫

  1. 探討穿心蓮內酯及其衍生物應用於胰臟癌之新穎分子機轉及治療潛力 (MOST 109-2320-B-010 -031 -MY3,主持人,2020/08/01~ 2023/07/31).
  2. 阿黴素抑制Cisd2表現及彭祖19號經由活化Cisd2降低阿黴素心毒性之分子機制探討(3/3) (MOST 110-2320-B-A49A-537,主持人,2021/08/01~ 2022/07/31).
  3. 防疫科學研究中心計畫,治療組,傳統中藥方劑對於新冠肺炎之臨床觀察及機轉探討(MOST 109-2327-B-010-005,子計畫主持人,2020/06/01~ 2021/12/31).
  4. 阿黴素抑制Cisd2表現及彭祖19號經由活化Cisd2降低阿黴素心毒性之分子機制探討(2/3) (MOST 109-2320-B-010 -044,主持人,2020/08/01~ 2021/07/31).
  5. 阿黴素抑制Cisd2表現及彭祖19號經由活化Cisd2降低阿黴素心毒性之分子機制探討(1/3) (MOST 108-2320-B-010-010,主持人,2019/08/01~ 2020/07/31).
  6. 探討穿心蓮內酯及其衍生物對致癌性p53點突變蛋白之抑制作用及抗癌應用性(106-2320-B-010-006-MY3,主持人,2017/08/01~ 2020/10/31).
  7. 抗發炎植物的研究與開發(106-2320-B-077-002-MY3,共同主持人,2017/08/01~ 2020/07/31).
  8. 探討hnRNPK蛋白質甲基化修飾促進癌細胞惡性之機制(106-2311-B-010-004-MY3,共同主持人,2017/08/01~ 2020/10/31).
  9. 九節茶、台灣及己和薄葉艾納香的活性組成研究(105-2320-B-077-003-,共同主持人,2016/08/01~ 2017/07/31).

實驗室介紹