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School of Chinese Medicine, College of Medicine, NYCU

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系所成員

Department members

花偉鈞 助理教授

關於

教師資料

學術著作

研究計畫

實驗室介紹

教師資料

現任

傳統醫藥研究所專案助理教授

學經歷

學歷

國立陽明交通大學分子醫學博士學位學程 博士
National Yang Ming Chiao Tung University and Academia Sinica, Taipei, Taiwan. Program in Molecular Medicine (Ph.D.)
國立陽明大學傳統醫藥研究所 碩士
National Yang-Ming University, Taipei, Taiwan.
Institute of Traditional Medicine (Master)
中國醫藥大學中國藥學暨中藥資源學系 學士
China Medical University, Taichung, Taiwan.
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources (Bachelor)

經歷
08/2024-07/2026 國立陽明交通大學 博士後研究員
05/2025-07/2025 日本橫濱藥科大學Yokohama University of Pharmacy訪問研究員

學術獎項
1. 第四十屆天然藥物研討會壁報論文獎-2025天然物藥理組第一名
2. 財團法人平安菁英教育基金會-2024菁英獎學金
3. 中華天然藥物學會優秀天然藥物學術論文獎-2024研究生論文獎
4. 第三十九屆天然藥物研討會壁報論文獎-2024天然物藥理組佳作
5. 國際傳統醫藥學術論文研討會-2023壁報獎
6. 第三十八屆天然藥物研討會壁報論文獎-2023傳統中醫藥組第三名
7. 國立陽明交通大學生醫學術論文研討會2023博士班組優等
8. 財團法人中華扶輪教育基金會-2022-23年度中華扶輪獎學金
9. 中華天然藥物學會優秀天然藥物學術論文獎-2022研究生論文獎
10.第三十七屆天然藥物研討會壁報論文獎-2022天然物藥理組佳作

研究專長
1. 中草藥抗癌分子機轉(Anticancer mechanisms of herbal medicine)
2. 標靶藥物抗藥性機制(Targeted therapy resistance)
3. 生物資訊與多體學分析(Bioinformatics and multi-omics)
4. 中藥網絡藥理學應用(TCM network pharmacology)

研究方向
1. 癌症獲得性抗藥性機制(Acquired drug resistance in cancer)
2. 中藥多體學與網絡藥理學整合分析 (Integrated multi-omics and network pharmacology in Chinese medicine research)

開設課程
中藥炮製及藥材學(含實驗) Herb processing of Chinese Medicine

專長

中草藥抗癌與標靶治療抗藥性機制、中藥網絡藥理學

學術著作

  1. Sang-Nguyen-Cao Phan#, Wei-Jyun Hua#, Li-Lan Liao, Zhi-Hu Lin, Diem-Ngoc-Hong Tran, Mei-Kuang Lu, Tung-Yi Lin*. The dual role of Ganoderma lucidum polysaccharides in cancer treatment: Meridian tropism-based direct inhibition and immune-mediated modulation. Journal of the Chinese Medical Association. 2026 Jul 6. (SCI, IF: 2.4, Rank: 23.4%, #co-first author)
  2. Wei-Hung Hsu, Zhi-Hu Lin, Huagang Shi, Wei-Lun Qiu, Hsin Yeh, Ai-Jung Tseng, Wei-Jyun Hua, Wei-Jie Wang, Tung-Yi Lin*. Enhancement of wound healing in patients with Hansen’s disease: The effects of Jinchuang ointment on anti-inflammation and cell migration. Journal of Ethnopharmacology. 2026 Apr 6:360:121171. (SCI, IF: 5.4, Rank: 11.1%)
  3. Wei-Jyun Hua, Li-Chen Huang, Zhi-Hu Lin, Yi-Ru Ciou, Kai-Fan Lin, Li-Lan Liao, Wei-Hung Hsu, Tung-Yi Lin*. Suppression of tumor growth by GMI, an edible fungal immunomodulatory protein, is associated with targeting GSK3β‑mediated proteasomal degradation of PD‑L1. International Journal of Molecular Medicine. 2025 Dec;56(6):217. (SCI, IF: 5.8, Rank: 20%, first author)
  4. Chueh-Tan Chen, Zhi-Hu Lin, Tung-Yi Lin, Yi-An Lin, Hsin Yeh, Wei-Jyun Hua, Ching Yao Tsai*. PM2.5 exposure induces transcriptomic changes in ARPE-19 cells with activation of TGFβ-mediated signaling pathways: A next-generation sequencing approach. Journal of the Chinese Medical Association. 2025 Nov 1;88(11):876-886. (SCI, IF: 2.4, Rank: 23.4%)
  5. Wei-Jyun Hua, Wei-Lun Hwang, Hsin Yeh, Zhi-Hu Lin, Wei-Hung Hsu, Tung-Yi Lin*. Ganoderma microsporum immunomodulatory protein combined with KRASG12C inhibitor impedes intracellular AKT/ERK network to suppress lung cancer cells with KRAS mutation. International Journal of Biological Macromolecules. 2024 Feb;259(Pt 2):129291. (SCI, IF: 8.5, Rank: 5.3%, first author)
  6. Wei-Jyun Hua, Hsin Yeh, Zhi-Hu Lin, Ai-Jung Tseng, Li-Chen Huang, Wei-Lun Qiu, Tsung-His Tu, Ding-Han Wang, Wei-Hung Hsu, Wei-Lun Hwang, Tung-Yi Lin*. Ganoderma microsporum immunomodulatory protein as an extracellular epidermal growth factor receptor (EGFR) degrader for suppressing EGFR-positive lung cancer cells. Cancer Letters. 2023 Dec 1:578:216458. (SCI, IF: 10.1, Rank: 9.1%, first author)
  7. Hung-Chih Lo#, Wei-Jyun Hua#, Hsin Yeh#, Zhi-Hu Lin, Li-Chen Huang, Yi-Ru Ciou, Runcheng Ruan, Kai-Fan Lin, Ai-Jung Tseng, Alexander T H Wu, Wei-Hung Hsu, Chi-Hong Chao, Tung-Yi Lin*. GMI, a Ganoderma microsporum protein, abolishes focal adhesion network to reduce cell migration and metastasis of lung cancer. Life Sciences. 2023 Dec 15:335:122255. (SCI, IF: 5.1, Rank: 12.5%, #co-first author)
  8. Chueh-Tan Chen, Chian-Feng Chen, Tung-Yi Lin, Wei-Jyun Hua, Kate Hua, Ching-Yao Tsai, Chung-Hua Hsu*. Traditional Chinese medicine Kuan-Sin-Yin decoction inhibits cell mobility via downregulation of CCL2, CEACAM1 and PIK3R3 in hepatocellular carcinoma cells. Journal of Ethnopharmacology. 2023 Dec 5:317:116834. (SCI, IF: 5.4, Rank: 11.1%)
  9. Zhi-Hu Lin, Hsin Yeh, Hung-Chih Lo, Wei-Jyun Hua, Ming-Yang Ni, Li-Kai Wang, Ting-Ting Chang, Muh-Hwa Yang, Tung-Yi Lin*. GMI, a fungal immunomodulatory protein, ameliorates SARS-CoV-2 envelope protein-induced inflammation in macrophages via inhibition of MAPK pathway. International Journal of Biological Macromolecules. 2023 Jun 30:241:124648. (SCI, IF: 8.5, Rank: 5.3%)
  10. Ai-Jung Tseng#, Tsung-Hsi Tu#, Wei-Jyun Hua#, Hsin Yeh, Ching-Jung Chen, Zhi-Hu Lin, Wei-Hung Hsu, Ying-Lan Chen, Chuan-Chih Hsu, Tung-Yi Lin*. GMI, Ganoderma microsporum protein, suppresses cell mobility and increases temozolomide sensitivity through induction of Slug degradation in glioblastoma multiforme cells. International Journal of Biological Macromolecules. 2022 Oct 31:219:940-948. (SCI, IF: 8.5, Rank: 5.3%, #co-first author)
  11. Hsin Yeh, Di Ngoc Kha Vo, Zhi-Hu Lin, Ha Phan Thanh Ho, Wei-Jyun Hua, Wei-Lun Qiu, Ming-Han Tsai, Tung-Yi Lin*. GMI, a protein from Ganoderma microsporum, induces ACE2 degradation to alleviate infection of SARS-CoV-2 Spike-pseudotyped virus. Phytomedicine. 2022 Aug:103:154215. (SCI, IF: 8.3, Rank: 2.2%)
  12. Wei-Lun Qiu, Wei-Hung Hsu, Shu-Ming Tsao, Ai-Jung Tseng, Zhi-Hu Lin, Wei-Jyun Hua, Hsin Yeh, Tzu-En Lin, Chien-Chang Chen, Li-Sheng Chen, Tung-Yi Lin*. WSG, a glucose-rich polysaccharide from Ganoderma lucidum, combined with cisplatin potentiates inhibition of lung cancer in vitro and in vivo. Polymers. 2021 Dec 13;13(24):4353. (SCI, IF: 4.9, Rank: 20.2%)
  13. Wei-Hung Hsu#, Wei-Jyun Hua#, Wei-Lun Qiu, Ai-Jung Tseng, Hsin-Chung Cheng, Tung-Yi Lin*. WSG, a glucose-enriched polysaccharide from Ganoderma lucidum, suppresses tongue cancer cells via inhibition of EGFR-mediated signaling and potentiates cisplatin-induced apoptosis. International Journal of Biological Macromolecules. 2021 Dec 15;193(Pt B):1201-1208. (SCI, IF: 8.5, Rank: 5.3%, #co-first author)
  14. Tung-Yi Lin*,#, Wei-Jyun Hua#, Hsin Yeh, Ai-Jung Tseng. Functional proteomic analysis reveals that fungal immunomodulatory protein reduced expressions of heat shock proteins correlates to apoptosis in lung cancer cells. Phytomedicine. 2021 Jan:80:153384. (SCI, IF: 8.3, Rank: 2.2%, #co-first author)
  15. Wei-Hung Hsu, Wei-Lun Qiu, Shu-Ming Tsao, Ai-Jung Tseng, Mei-Kuang Lu, Wei-Jyun Hua, Hsin-Chung Cheng, Hsien-Yeh Hsu, Tung-Yi Lin*. Effects of WSG, a polysaccharide from Ganoderma lucidum, on suppressing cell growth and mobility of lung cancer. International Journal of Biological Macromolecules. 2020 Dec 15;165(Pt A):1604-1613. (SCI, IF: 8.5, Rank: 5.3%)
  16. Wei-Lun Qiu, Ai-Jung Tseng, Hsien-Yeh Hsu, Wei-Hung Hsu, Zhi-Hu Lin, Wei-Jyun Hua, Tung-Yi Lin*. Fucoidan increased the sensitivity to gefitinib in lung cancer cells correlates with reduction of TGFβ-mediated Slug expression. International Journal of Biological Macromolecules. 2020 Jun 15:153:796-805. (SCI, IF: 8.5, Rank: 5.3%)

研究計畫

國科會計畫：
1. 探討靈芝免疫調節蛋白質靶向獲得性抗藥性路徑以克服肺癌KRAS G12C抑制劑的作用機制。2026.08.01-2029.07.31。主持人

實驗室介紹

本實驗室以中藥網絡藥理學為核心，結合生物資訊、多體學分析及分子與細胞生物學技術，探討中藥多成分、多靶點的作用機轉，並透過細胞與動物實驗進行驗證。研究聚焦於兩大方向：（一）建立癌症標靶藥物抗藥性模型，解析獲得性抗藥機轉，並評估中草藥及其活性成分延緩或逆轉抗藥性的潛力；（二）整合成分與靶點預測、網絡分析、路徑富集及分子對接，鑑定中藥複方、單味藥與炮製品的關鍵成分、核心靶點及作用路徑，以推動中醫藥實證與現代化研究。