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Department Members

系所成員

Yi-Tsau Huang

教師資料

學術著作

研究計畫

實驗室介紹

教師資料

現任

中醫系專任 傳醫所合聘

學歷

  • 英國格拉斯哥大學臨床藥理所/博士(1991)
    Ph.D. , University of Glasgow, United Kingdom
  • 國立陽明醫學院醫學系/學士(1984)
    M.D., National Yang-Ming Medical College, Taiwan

專長

1.中醫藥政策; 2. 中醫藥國際交流與合作; 3. 近年國際重要中醫藥研究論文評介。

學術著作

A. Original Papers

  1. Huang, Y.-T., Hamilton, C.A., and Reid, J.L. 1989. Endothelin stimulates phosphatidylinositol hydrolysis in rat vascular smooth muscle. J. Hypertens. 7: 703-705. (sci)
  2. Hamilton, C.A., Huang, Y.-T., and Reid, J.L. 1992. Effects of endothelin upon blood pressure in normotensive rabbits and in perinephritis hypertension. J. Hypertens. 10: 787-794. (sci)
  3. Hamilton, C.A., Boyle, J.J., Huang, Y.T., McCulloch, J., Nixon, G.F., and Pryadarshi, S. 1994. Agonist desensitisation of a1-adrenoceptors and endothelin-1 receptors coupled to phosphatidylinositol metabolism. Fundam. Clin. Pharmacol. 8: 162-172. (sci)
  4. Huang, Y.-T., Lo, J.-W., Lin, H.-C., Tsai, Y.-T., Hong, C.-Y., and Yang, M.C.M. 1995. Change in vascular cAMP and cGMP contents in portal hypertensive rats. Pharmacology 50: 86-91. (sci)
  5. Huang, Y.-T., Yu, P.-C., Lee, M.-.F., Lin, H.-C., Hong, C.-Y., and Yang, M.C.M. 1995. Decreased vascular contractile and inositol phosphate responses in portal hypertensive rats. Can. J. Physiol. Pharmacol. 73: 378-382. (sci)
  6. Huang, Y.-T., Wang, G.-F., Chen, C.-F., Chen, C.-C., Hong, C.-Y., and Yang, M.C.M. 1995. Fructus Aurantii reduced portal pressure in portal hypertensive rats. Life Sci. 57: 2011-2020. (sci)
  7. Hong, C.Y., Lai, L.J., and Huang, Y.T. 1995. Endothelium-dependent vasorelaxant effect of trilinolein: mediated by nitric oxide and cGMP. Life Sci. 57: 1309-1315. (sci)
  8. Huang, Y.-T., Lin, H.-C., Yu, P.-C., Lee, F.-.Y., Tsai, Y.-T., Lee, S.-D., and Yang, M.C.M. 1996. Decreased vascular reactivity of portal vein in rats with portal hypertension. J. Hepatol. 24: 194-199. (sci)
  9. Huang, Y.-T., Wang, G.-F., Yang, M.C.M., Chang, S.-P., Lin, H.-C., and Hong, C.-Y. 1996. Vascular hyporesponsiveness in aorta from portal hypertensive rats: possible sites of involvement. J. Pharmacol. Exp. Ther. 278: 535-541.  (sci)
  10. Huang, Y.-T., Tsai, J.-F., Liu, T.-B., Hong, C.-Y., Yang, M.C.M., and Lin, H.-C. 1996. Chronic administration of octreotide improves vascular responsiveness in portal hypertensive rats. Clin. Sci. 91:601-606. (sci)
  11. Lin, H.-C., Yang, M.C.M., Ho, M.-C., Lee, F.-Y., Huang, Y.-T., Lin, L.-F., Li, S.-M., Hwang, S.-S., Wang, S.-S., Tsai, Y.-T., and Lee, S.-D. 1996. Hyperglucagonemia in cirrhotic patients and its relationship to the severity of cirrhosis and hemodynamic values. J. Gastroenterol. Hepatol. 11: 422-428. (sci)
  12. Lin, H.-C., Yang, M.C.M., Ho, M.-C., Li, S.-M., Huang, Y.-T., Yu, P.-C., Tsai, Y.-T., and Lee, S.-D. 1996. Effects of long-term administration of octreotide in portal vein-stenosed rats. Hepatology 23: 537-543. (sci)
  13. Huang, Y.-T., Chang, S.-P., Lin, H.-C., Yang, M.C.M., and Hong, C.-Y. 1997. Inositol phosphate responses in portal veins from portal hypertensive rats: receptor- and nonreceptor-mediated responses. J. Hepatol. 26: 376-381. (sci)
  14. Liu, T.-B., Lin, H.-C., Huang, Y.-T.*, Sun, C.-M., and Hong, C.-Y. 1997. Portal hypotensive effects of tetrandrine and verapamil on portal hypertensive rats. J. Pharm. Pharmacol. 49: 85-88. (sci)   (*Corresponding author)
  15. Lin, H.-C., Yang, M.C.M., Huang, Y.-T., Yu, P.-C., Ho, M.-C., Hong, C.-Y. and Lee, S.-D. 1997. The hemodynamic effects of AT-112, an analog of ketanserin, in portal vein-stenosed rats. Pharmacology 54: 16-23. (sci)
  16. Huang, Y.-T., Lin, H.-C., Tsai, J.-F., Hou, M.-C., and Hong, C.-Y. 1997. Chronic administration of propranolol improves vascular contractile responsiveness in portal hypertensive rats. Eur. J. Clin. Invest. 27: 550-555. (SCI)
  17. Huang, Y.-T., Liu, T.-B., Lin, H.-C., Yang, M.C.M., and Hong, C.-Y. 1997. Hemodynamic effects of chronic tetrandrine and propranolol administration on portal hypertensive rats. Pharmacology 54: 225-231. (sci)
  1. Huang, Y.-T., Cheng, Y.-R., Lin, H.-C., Chen, C.-F., and Hong, C.-Y. 1997. Haemodynamic effects of chronic tetrandrine treatment in portal hypertensive rats. J. Gastroenterol. Hepatol. 12: 585-589. (sci)
  2. Huang, Y.-T., Liu, T.-B., Cheng, Y.-R., Lin, H.-C., Chen, C.-F., and Chen, S.-M. 1997. Chronic portal hypotensive effects of tetrandrine and verapamil on portal hypertensive rats. Asia Pac. J. Pharmacol. 12: 31-35. (sci)
  3. Huang, Y.-T., Cheng, Y.-R., Lin, H.-C., Chen, C.-F., and Hong, C.-Y. 1997. Haemodynamic effects of chronic tetrandrine treatment in Sprague-Dawley rats. Chin. J. Physiol. 40: 175-178.
  4. Huang, Y.-T., Tsai, J.-F., Lin, H.-C., Chen, C.-F., and Hong, C.-Y. 1997. Hemodynamic effects of acute tetrandrine and terlipressin administration on portal hypertensive rats. Can. J. Physiol. Pharmacol. 40:1220-1225. (sci)
  1. Huang, Y.-T., Cheng, Y.-R., Lin, H.-C., Hou, M.-C., Lee, S.-D., and and Hong, C.-Y. 1998. Hemodynamic effects of eight-day octreotide and propranolol administration in portal hypertensive rats. Dig. Dis. Sci. 43:358-364. (sci)
  2. Huang, Y.-T., Cheng, Y.-R., Lin, H.-C., Chen, S.-M., and Hong, C.-Y. 1998. Haemodynamic effects of chronic octreotide and tetrandrine treatment in portal hypertensive rats. J. Gastroenterol. Hepatol. 13:266-272. (sci)
  1. Huang, Y.-T., Lin, H.-C., Tsai, J.-F., Hou, M.-C., Lee, S.-D., and Hong, C.-Y. 1998. Vascular hyporeactivity persists despite increased contractility after long-term administration of isosorbide dinitrate in portal hypertensive rats. J. Hepatol. 28: 1037-1044. (sci)
  1. Lin, H.-C., Huang, Y.-T., Cheng, Y.-R., Hou, M.-C., Lee, F.Y., Chang, F.-Y., Tsai, Y.-T., and Lee, S.-D. 1998. Effect of long-term octreotide and isosorbide dinitrate on haemodynamics in rats with portal vein stenosis. Clin. Sci. 94: 645-650. (sci)
  1. Huang, Y.-T., Lin, L.-C., Chern, J.-W., Lin, H.-C., and Hong, C.-Y. 1998. Portal hypotensive effects of DL-028 and prazosin on portal hypertensive rats. Pharmacology 57: 132-138. (sci)
  2. Chang, F.-C., Chen, K.-J., Lin, J.-G., Hong, C.-Y., and Huang, Y.-T. 1998. Portal hypotensive effects of tetramethylpyrazine on portal hypertensive rats. J. Pharm. Pharmacol. 50: 881-884. (sci)   (Corresponding author)
  3. Lin, H.-C., Wu, H.-L., Huang, Y.-T.*, Hou, M.-C., and Hong, C.-Y. 1998. Haemodynamic effects of eight-day octreotide and prazosin administration in portal hypertensive rats. Eur. J. Clin. Invest. 28: 622-628. (sci) (*Corresponding author)
  4. Huang, Y.-T., Wu, H.-L., Chern, J.-W., Lin, L.-C., and Hong, C.-Y. 1998. Hemodynamic effects of eight-day DL-028 and octreotide administration in portal hypertensive rats. Scand. J. Gastroenterol. 33: 1303-1309. (sci)
  5. Huang, Y.-T., Chang, F.-C., Chen, K.-J., and Hong, C.-Y. 1999. Acute hemodynamic effects of tetramethylpyrazine and tetrandrine on cirrhotic rats. Planta Med. 65: 130-134.. (sci)
  6. Huang, Y.-T., Lin, L.-C., Chern, J.-W., Lin, H.-C., and Hong, C.-Y. 1999. Portal hypotensive effects of combined terlipressin and DL-028 on anesthetized portal hypertensive rats. Liver 19: 129-134. (sci)
  7. Chang, F.-C., Huang, Y.-T.*, Hong, C.-Y., Lin, J.-G., and Chen, K.-J. 1999. Haemodynamic effects of chronic tetramethylpyrazine administration on portal hypertensive rats. Eur. J. Gastroenterol. Hepatol. 11: 1027-1031. (sci) (*Corresponding author)
  8. Lin, H.-C., Huang, Y.-T., Wu, H.-L., Lee, W.-C., Hou, M.-C., Lee, F.-Y., Chang, F.-Y., and Lee, S.-D. 1999. Hemodynamic evaluation of prolonged-release lanreotide in rats with portal vein stenosis. J. Hepatol. 31: 482-488. (sci)
  1. Chang, F.-C., Huang, Y.-T.*, Lin, H.-C., Hong, C.-Y., Lin, J.-G., and Chen, K.-J. 1999. Beneficial effects of combined terlipressin and tetramethylpyrazine administration on portal hypertensive rats. Can. J. Physiol. Pharmacol. 77: 618-624. (sci) (*Corresponding author)
  1. Huang, Y.-T., Lin, H.-C., Chang, Y.-Y., Yang, Y.-Y., Chang, F.-Y., and Lee, S.-D. 2001. Hemodynamic effects of synephrine in portal hypertensive rats. Jpn. J. Pharmacol. 85: 183-188. (sci)
  1. Huang, Y.-T., Lee, T.-Y., Lin, H.-C., Chou, T.-Y., Yang, Y.-Y., and Hong, C.-Y. 2001. Hemodynamic effects of Salvia miltiorrhiza on cirrhotic rats. Can. J. Physiol. Pharmacol. 79: 566-572. (sci)
  1. Yang, Y.-Y., Lin, H.-C., Huang, Y.-T., Lee, T.-Y., Lee, W.-C., Hou, M.-C., Lee, F.-Y., Chang, F.-Y., and Lee, S.-D.2001. Adaptive vasodilatory response after octreotide treatment. Am. J. Physiol. 281: G117-G123. (sci)
  2. Yang, Y.-Y., Lin, H.-C., Huang, Y.-T., Lee, T.-Y., Hou, M.-C., Lee, F.-Y., Liu, R.-S., Chang, F.-Y., and Lee, S.-D. 2002. Effect of 1-week losartan administration on bile duct-ligated cirrhotic rats with portal hypertension. J. Hepatol. 36: 600-606. (sci)
  3. Huang, Y.-T., Hsu, Y.-C., Chen, C.-J., Liu, C.-T., and Wei., Y.-H. 2003.Oxidative stress related changes in the liver of bile duct ligated rats. J. Biomed. Sci. 10: 170-178. (sci)
  4. Hsu Y-T, Chiu Y-T, Lee C-Y, Lin Y-L, Huang, Y.-T.* 2004. Increases in fibrosis-related gene transcripts in dimethylnitrosamine-intoxicated rat livers J. Biomed. Sci. ;11:408-417. (sci) (*Correponding author)
  1. Hsu Y-T, Lin Y-L, Chiu Y-T, Shiao M-S, Lee C-Y, Huang, Y.-T.* 2005. Anti-fibrotic effects of Salvia miltiorrhiza on dimethylnitrosamine-intoxicated rats. J. Biomed. Sci., 12:185-195. (sci) (*Correponding author)
  1. Lin Y-L, Lee T-F, Huang Y-J, Huang, Y.-T.* 2006. Inhibitory effects of Ligusticum chuanxiong on the proliferation of rat hepatic stellate cell. J. Gastroenterol. Hepatol. 21:1257-1265. (sci) (*Correponding author)
  2. Lin Y-L, Wu C-H, Luo M-H, Huang Y-J, Wang C-N, Shiao M-S, Huang, Y-T*. 2006. In vitro protective efects of salvianolic acid B on primary hepatocytes and hepatic stellate cells. J. Ethnopharmacol. 105:215-222. (sci) (*Correponding author)
  1. ChongL-W, Hsu Y-C, Chiu Y-T, Yang K-C, Huang, Y.-T.* 2006. Antifibrotic effects of thalidomide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats. J. Biomed. Sci, 13: 403-418. (sci) (*Correponding author)
  2. Lin Y-L, Lee T-F, Huang Y-J, Huang, Y-T.* 2006. Antiproliferative effect of salvianolic acid A on rat hepatic stellate cells. J. Pharm. Pharmacol. 58: 933-939. (sci) (*Correponding author)
  3. Hsu Y-C, Chiu Y-T, Lee C-Y, Wu C-F, Huang, Y.-T.* 2006. Antifibrotic effects of tetrandrine on bile duct ligated rats. Can. J. Physiol. Pharmacol. 84: 967-976. (sci) (*Correponding author)
  4. Hsu Y-C, Chiu Y-T, Cheng C-C, Wu C-F, Lin Y-L, Huang, Y.-T.* 2007. Antifibrotic effects of tetrandrine on hepatic stellate cells and rats with liver fibrosis. J. Gastroenterol. Hepatol. 22:99-111. (sci) (*Correponding author)
  5. Lee T-F, Lin Y-L, Huang, Y.-T.* 2007. Anti-proliferative effects of phthalides from Ligusticum chuanxiong in hepatic stellate cells. Planta Med. 73:527-534. (sci) (*Correponding author)
  6. Lin Y-L, Hsu Y-C, Chiu Y-T, Huang Y.-T.* 2008. Anti-fibrotic effects of a herbal combination regimen on hepatic fibrotic rats. Phytother. Res. 22: 69-76. (sci) (*Correponding author)
  7. Chang L-C, Huang N, Chou Y-J, Kao F-Y, Hsieh P-C, Huang, Y.-T.* 2008. Patterns of combined prescriptions of aspirin-Ginkgo biloba in Taiwan: a population-based study. J. Clin. Pharm. Ther. 33:243-249. (sci) (*Correponding author)
  8. Chang L-C, Huang N, Kao F-Y, Lee C-H, Chou Y-J, Huang, Y.-T.* 2008. Utilization patterns of Chinese medicine and Western medicine under the National Health Insurance Program in Taiwan, a population-based study from 1997 to 2003. BMC Health Serv. Res.,8: 170. (sci) (*Correponding author)
  1. Lin Y-L, Wu C-F, Huang, Y.-T.* 2008. Effects of Rhubarb on migration of rat hepatic stellate cells. J. Gastroenterol. Hepatol.. 24: 453-461. (sci) (*Correponding author)
  2. Lin Y-L, Lin C-Y, Chi C-W, Huang, Y.-T.* 2009. Study on antifibrotic effects of curcumin in rat hepatic stellate cells. Phytother. Res. 23: 927-932.(sci). (*Correponding author)
  3. Weng T-C, Shen C-C, Chiu Y-T, Kuo, C-D, Lin Y-L, Huang, Y.-T.* 2009. Inhibitory effects of armepavine against hepatic fibrosis in rats. J. Biomed. Sci. 16: 78-90. doi:10.1186/1423-0127-16-78. (sci) (*Correponding author)
  4. Tsai M-K, Lin Y-L, Huang, Y.-T.* 2010. Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats. Toxicol. Appl. Pharmacol. 242:155-164. (sci) (*Correponding author)
  5. Chong L-W, Hsu Y-C, Chiu Y-T, Yang K-C, Huang, Y.-T.* 2011. Anti-fibrotic effects of triptolide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats. Phytother. Res. 25: 990-999. (sci) (*Correponding author)
  6. Tsai M-K, Lin Y-L, Huang, Y.-T.* 2011. Differential inhibitory effects of salvianolic acids on activation of rat hepatic stellate cells by platelet-derived growth factor. Planta Med. 77:1495-1503. (sci) (*Correponding author)
  7. Lee T-F, Lin Y-L, Huang, Y.-T.* 2011. Kaerophyllin inhibits hepatic stellate cell activation by apoptotic bodies from hepatocytes. Liver Int. 31: 618-629. (sci) (*Co-senior author)
  1. Weng T-C, Shen C-C, Chiu Y-T, Lin Y-L, Huang Y-T.* Effects of armepavine against hepatic fibrosis induced by thioacetamide in rats. Phytother. Res. 26: 344-353. (Sci) (*Correponding author)
  2. Lee T-F, Lin Y-L, Huang Y-T..* 2012. Protective effects of kaerophyllin against liver fibrogenesis in rats. Eur. J. Clin. Invest. 42: 607-616.. (sci) (*Correponding author)
  3. Wu C-F, Lin Y-L, Huang Y-T.* 2013. Hepatitis C virus core protein stimulates fibrogenesis in hepatic stellate cells involving the obese receptor. J. Cell. Biochem. 114: 541–550. (sci) (*Correponding author)
  4. Liu Y-W, Huang Y-T.* 2014. Inhibitory effect of tanshinone IIA on rat hepatic stellate cells. Plos ONE e103229. (sci) (*Correponding author)

 

  1. Chong L-C, Hsu Y-C, Lee T-F, Lin Y, Chiu Y-T, Yang K-C, Wu J-C, Huang Y-T.* Fluvastatin attenuates hepatic steatosis-induced fibrogenesis in rats through inhibiting paracrine effect of hepatocyte on hepatic stellate cells. BMC Gastroenterol., 15:22. DOI 10.1186/s12876-015-0248-8. (sci) (*Correponding author)

 

  1. Liu Y-W, Chiu, Y-T, Fu S-L, Huang Y-T.* 2015. Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation. J. Biomed. Sci. 22:63. doi:10.1186/s12929-015-0168-5. (sci) (*Correponding author)

 

B. Review Articles

  1. Huang Y.-T.* , and Hong, C.-Y. 1997. Current studies of traditional Chinese medicine: a review. J. Food Drug Anal. 5: 265-272. (sci)  (*Correponding author)
  1. Huang Y.-T., and Hong, C.-Y. 1998. Alternative medicine-Formulary evaluation in Asia. Med. Prog. 25 (June): 5-7.
  2. Huang Y.-T., and Hong, C.-Y. 1998. Tetrandrine. Cardiovasc. Drug Rev. 16: 1-15. (sci) (*Correponding author)
  3. Bomzon, A., and Huang, Y.-T. 2001. Vascular smooth muscle cell signaling in cirrhosis and portal hypertension. Pharmacol. Ther. 89:255-272. (sci)
  4. Chen H.-H., Tsai S.-L., You W.-R., Chen C.-J., Chen P.-C., Lin M.-C., Chu W.-J., Huang Y.-T.* 2018. Current status and outlook on the development of traditional Chinese medicine in Taiwan. J. Formos. Med. Assoc., 117;544-546. (SCI) (*Correponding author)
  5. Hsieh T.-P., You W.-R., Lin M.-C., Huang C.-Y., Huang Y.-T.*2021. Promotion of Taiwan Chinese medicine and pharmacy development act. J. Formos. Med.  Assoc., 120;1049-1050. (SCI) (*Correponding author)

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